Tolerance to analgesic properties of buprenorphine and morphine peridurally administered. A cross over study
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چکیده
منابع مشابه
Intrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats
Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...
متن کاملSingle dose tolerance to the analgesic effect of clonidine and cross-tolerance between morphine and clonidine.
A single dose of clonidine developed tolerance to its analgesic effect. The tolerance reached its peak acutely on the 2nd day and lasted more than 5 days. Neither the analgesic effect nor the development of tolerance was modified by the pretreatment with naloxone. On the 2nd day, clonidine tolerant animals were also tolerant to morphine, but morphine tolerant animals, after a single dose of mor...
متن کاملMechanisms underlying morphine analgesic tolerance and dependence.
The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanism...
متن کاملVoluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats
Objective(s):Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the roles of voluntary and forced exercises in tolerance to analgesic effect of...
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cognitive studies of translation process have recently been awarded a great deal of attention. there exists a psychological angle to almost all translation activities. the present study, thus, deals with analysing the relationships between iranian prospective translators tolerance for ambiguity (ta) and their willingness to translate (wtt). the research was conducted as a mixed methods study, d...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 1988
ISSN: 0885-3924
DOI: 10.1016/0885-3924(88)90055-3